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Francis Amory Prize Ceremony and Symposium

House of the Academy, Cambridge, MA
March 14, 2012

Click Video for individual recordings.
David C. Page is Director of the Whitehead Institute, Professor of Biology at the Massachusetts Institute of Technology, and a Howard Hughes Medical Institute Investigator. His laboratory studies the foundations of mammalian reproduction, with particular attention to the X and Y chromosomes, infertility, and the fetal origins of sex cells–the precursors of eggs and sperm. He has reconstructed the evolution of today’s X and Y chromosomes from an ancestral pair of chromosomes that existed 300 million years ago, and discovered molecular evolutionary mechanisms by which the Y chromosome became functionally specialized in spermatogenesis. He discovered and characterized the most common genetic cause of spermatogenic failure in humans: deletion of the AZFc region of the Y chromosome. Most recently, he found that aberrant crossing-over within the Y chromosome’s palindromes underlies a wide range of disorders of sexual differentiation, including Turner syndrome. His honors include a MacArthur Prize Fellowship, Science magazine’s Top Ten Scientific Advances of the Year (1992 and 2003), the 1997 Francis Amory Prize of the American Academy, and the 2011 March of Dimes Prize in Developmental Biology. He is a Member of the National Academy of Sciences and the Institute of Medicine. He was elected a Fellow of the American Academy of Arts and Sciences in 2011.
Video (14 mins)
Patricia K. Donahoe is Director of the Pediatric Surgical Research Laboratories and Chief Emerita of Pediatric Surgical Services at Massachusetts General Hospital and Marshall K. Bartlett Professor of Surgery at Harvard Medical School. Her research focuses on the genetics of congenital anomalies, including the examination of targetable differences between ovarian somatic and cancer stem cells, and the role of Mullerian Inhibiting Substance (MIS) as a therapeutic for ovarian and other reproductive cancers. She is an Associate Member of the Broad Institute, a Principal Faculty Member of the Harvard Stem Cell Institute, and an Associate Faculty member of the Center for Human Genomic Research at Massachusetts General Hospital. She is the 2011 recipient of the Society of University Surgeons Lifetime Achievement Award. She is a member of the National Academy of Sciences and the Institute of Medicine and was elected a Fellow of the American Academy of Arts and Sciences in 1987.
Video (16 mins)
Patrick C. Walsh is University Distinguished Service Professor of Urology at Johns Hopkins Medical Institutions. He served as Director of the James Buchanan Brady Urological Institute at Johns Hopkins University School of Medicine from 1974 to 2004. He is widely recognized for his pioneering work in the development of the anatomic approach to radical prostatectomy, which involves nerve-sparing techniques that have reduced the probability of impotence and incontinence. He has also made major contributions to the basic understanding of benign and malignant neoplasms of the prostate. He is on the editorial board of the New England Journal of Medicine and for twenty-five years served as Editor-in-Chief of Campbell’s Textbook of Urology, which has been renamed Campbell Walsh in his honor. He was honored as the 2007 National Physician of the Year for Clinical Excellence and was the co-recipient of the 2007 King Faisal International Prize in Medicine. He also received the Charles F. Kettering Medal in 1996. He is the recipient of the 2012 Francis Amory Prize of the American Academy. His publications include The Prostate: A Guide for Men and the Women Who Love Them (1995) and Dr. Patrick Walsh’s Guide to Surviving Prostate Cancer (2001). He is a member of the Institute of Medicine.
Video (12 mins)

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