Biochemistry, Biophysics, and Molecular Biology
International Honorary Member
Discovery of the oncogenic role of mutated retinoic acid receptor fusion proteins and unravelling the molecular and cellular basis for the complete cure of Acute Promyelocytic Leukemia (APL) by a combination of retinoic acid and arsenic. This is the best paradigm for differentiation-induced cancer therapy. Pioneering studies on the biological functions of SUMOylation and uncovering its major role in controlling chromatin function, innate immunity and cell fate decisions. She is one of the world leaders in the SUMO field, a ubiquitin-like covalent protein modification with a major role in gene control.