Bruce R. Rosen

Rosen is the primary architect of the imaging modality functional magnetic resonance imaging (fMRI). He developed the paradigm of dynamic susceptibility weighted imaging of cerebral hemodynamics, provided a detailed mathematical framework for the quantification of physiological parameters from fMRI data, and extended the methods to the measurement of novel biophysical tissue features, including the assessment of microvascular size distribution and tissue oxygenation. His laboratory was the first to extend this paradigm to the study of human brain functional activation and has established conceptual and analytic methods for assessment of cognitive functions using block-and event-related task designs to study normal human brain function and a wide variety of neuropathologies.