Christopher P. Hill

Hill has combined cutting edge structural studies and biochemistry with clever mechanistic insights to make seminal discoveries across a remarkable range of biology and medicine, most notably in determining the structures and activities of a series of important molecular machines that function in the ubiquitin/proteasome system, protein unfolding, HIV biology, nucleosome remodeling, transcription, RNA editing, porphyrin synthesis and metabolism and bacterial motility. A significant recent accomplishment has been to decipher the structures and mechanisms of AAA+ ATPases, which are cellular workhorses that unfold polypeptide substrates during such diverse processes such as protein disaggregation, HIV budding and microtubule severing.