Christopher P. Hill

University of Utah School of Medicine
Biological Sciences
Biochemistry, Biophysics, and Molecular Biology

Hill has combined cutting edge structural studies and biochemistry with clever mechanistic insights to make seminal discoveries across a remarkable range of biology and medicine, most notably in determining the structures and activities of a series of important molecular machines that function in the ubiquitin/proteasome system, protein unfolding, HIV biology, nucleosome remodeling, transcription, RNA editing, porphyrin synthesis and metabolism and bacterial motility. A significant recent accomplishment has been to decipher the structures and mechanisms of AAA+ ATPases, which are cellular workhorses that unfold polypeptide substrates during such diverse processes such as protein disaggregation, HIV budding and microtubule severing.

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