Daniel E. Gottschling

Gottschling pioneered methods for analyzing fundamental biological processes in yeast, with which he elucidated the relationship between telomeres and transcriptional silencing, facilitating a mechanistic understanding of eukaryotic epigenetic regulation; and discovered yeast telomerase RNA, novel modes of chromatin regulation, links between aging and genomic instability, and nuclear protein quality control. Current research focuses on understanding how organelles decline with age and how interconnectivity between organelles modulates the aging process.