David A. Agard
University of California, San Francisco
Biochemistry, Biophysics, and Molecular Biology
Professor of Biochemistry and Biophysics; Investigator, Howard Hughes Medical Institute. With Sedat, revolutionized optical fluoresence microscopies that extend resolution two-fold and automated three-dimensional electron tomography applied to centrosome and chromosome structures. Redefined mechanisms of microtubule nucleation and growth, mechanisms of the estrogen receptor, the roles of its natural chaperone Hsp90 and experimental mapping of protein folding.