David S. Pellman

I am the Margaret M. Dyson Professor of Pediatric Oncology at the Dana-Farber Cancer Institute, a Professor of Cell Biology at Harvard Medical School, an Investigator of the Howard Hughes Medical Institute, and the Associate Director for Basic Science at the Dana-Farber/Harvard Cancer Center. My lab studies cell division, cell division and chromosome segregation errors in cancer, and the impact of these errors on genome evolution and structure. The lab uses genetics, biochemistry and live-cell imaging. We developed a method to combine long-term live-cell imaging with single cell isolation and single cell genomics (Look-Seq). Look-Seq enables a cell's morphological phenotype to be directly related to a its genotype (or transcriptome). The mutational processes studied in his group are particularly important for cancer, but have relevance for genome evolution in other contexts. I received undergraduate and medical degrees from the University of Chicago. During medical school, I did research at the Rockefeller University. My postdoctoral fellowship was at the Whitehead Institute/Massachusetts Institute of Technology.