Ernest Peter Geiduschek

Research centered on gene regulation, more specifically on the enzymology of transcription and transcriptional regulation. In earlier work, his laboratory delineated sequences of genome transcription governing the multiplication cycles of bacterial viruses, established the general structures of their regulatory logic, and identified regulatory genes. In more recent work, his laboratory has unraveled novel biochemical mechanisms underlying gene regulation coupled to genome duplication (in a bacterial virus). His laboratory's research on eukaryotic transcription has established important principles of transcription factor function and RNA chain elongation. Recently initiated work focuses on transcription and transcriptional regulation in the Archaea.