Howard Y. Chang
Biochemistry, Biophysics, and Molecular Biology
Chang is a physician-scientist who has made major contributions in genome science. He discovered a new class of genes, termed long noncoding RNAs, which is pervasive in the human genome and tremendously important for biology and medicine. He discovered that long noncoding RNAs are important causes of human disease, notably cancer. Chang invented new genome-scale technologies from scratch to tackle the vastness of the noncoding genome. These technologies are widely used by thousands of scientists across the world and revolutionized the study of all living things.