Ian Andrew Wilson

Research contributions from my laboratory over the past 35 years have contributed to many of the pioneering studies on structural and functional characterization of key antigen recognition receptors in innate and adaptive immunity, including T cell receptors, MHC class I and II, over 175 antibodies and antibody complexes, CD1, TLRs, VLRs etc. etc.   We focus on immune recognition of microbial pathogens and on structure determination of challenging glycoproteins, including TLRs, NLRs, VLRs and TCRs and viral antigens such as HIV-1 Env, influenza HA and NA, and HCV E2. Our current focus is on identifying the sites of vulnerability on viral pathogens (HIV-1, influenza virus and HCV) that are targeted by broadly neutralizing antibodies, why these antibodies are so effective, and how we can use this information for structure-based vaccine design. As PI of the Joint Center for Structural Genomics, we also have considerable expertise in high-throughput methods for crystallization and x-ray structure determination of macromolecules.