Jason G. Cyster
University of California, San Francisco
Cellular and Developmental Biology
Cyster defined how lymphoid microenvironments are organized into secondary lymphoid tissues to support adaptive immunity. His researched played a role in the discovery of chemokines that continuously guide cells to lymphoid tissue sub-compartments. His work showed that changing responsiveness to these cues following antigen encounter repositions cells to favor interactions necessary for effective immune responses. He also sought to define how cells egress from the thymus and peripheral lymphoid tissues, a process essential for immune function. His studies have revealed the locations of antigen-encounter and immune cell migration dynamics for optimal immune responses.