Jeffrey H. Miller

Studies molecular mechanisms of mutagenesis and DNA repair. Using the lac operon of E. coli, devised method of determining DNA sequence changes of mutations. Illuminated array of mutational mechanisms including spontaneous mutations, mutational hot spots, deletions, gene amplifications and insertions, and mechanisms for mutagenic agents. Mutator gene studies revealed mechanisms influencing inherent mutation rates, including repair enzymes, mutant transfer-RNAs, specific efflux pumps, and nucleoside diphosphate metabolism. Authored several books, including Experiments in Molecular Genetics, (1972), A Short Course in Bacterial Genetics, (1992) and Discovering Molecular Genetics, (1996). Co-authored Introduction to Genetic Analysis, from 1985-2002, and I, Microbiologist, (2010), and co-editied The Encyclopedia of Genetics, 2001 vol. 1-4. Received Career Achievement Award of the Environmental Mutagen Society (2007).