Jonathan A. Ellman

He has discovered new reactions and procedures that directly benefit chemistry, chemical biology, and medicine.  He introduced the combinatorial synthesis of drug-like molecules, as first demonstrated for 1,4-benzodiazepines and then applied to many different compound classes and biomolecular targets, including compound classes that target protein families and protease substrate profiling methods. He developed the first method to produce enantiomerically pure tert-butanesulfinamide and pioneered its now extensive use for asymmetric amine synthesis. He made early and extensive contributions to catalytic C-H bond functionalization in organic synthesis, including C-C bond formation, enantioselective catalytic transformations, and nitrogen heterocycle and complex molecule synthesis.