Sid Gilman

Director, Michigan Alzheimer''s Disease Research Center. Biochemical changes in neurodegenerative diseases studied with positron emission tomography. Discovered the cerebral disorders resulting from open heart operations. Demonstrated generalized cerebral glucose hypermetabolism in Friedreich''s ataxia, focal cerebral hypometabolism in chronic alcoholism, olivopontocerebellar atrophy and multiple system atrophy, and preservation of benzodiazepine receptors in these disorders. Demonstrated an association between cerebral dopamine levels and rapid eye movement (REM) sleep behavior disorder and an association between cerebral acetylcholine levels and obstructive sleep apnea.