She established Toshiko Mori Architects in 1981 in New York City. Her specific area of interest is in materials and fabrication methods for architecture and in constantly using both new and traditional materials and techniques for integration of architecture with light and landscape. Strong research-based approach to design has been commended in invitations to lectures and conferences around the world. Designed institutional projects for Brown University and Syracuse University, and is part of the design team for New York University's master plan. Also designed the award winning Visitor Center at Frank Lloyd Wright's Darwin D. Martin House compound in Buffalo, New York, as well as the Center of Excellence in Environmental and Energy Systems for Syracuse University.