On April 17, 2025, Anthony S. Fauci, M.D., was honored with the American Academy’s Award for Excellence in Public Policy and Public Affairs. The award recognizes individuals for their distinction, independence, effectiveness, and work on behalf of the common good. The award was presented to Dr. Fauci for his significant contributions to the understanding and treatment of infectious diseases, including HIV/AIDS, tuberculosis, malaria, and COVID-19. The event included remarks by Dr. Fauci and an interview with Academy President Laurie L. Patton. An edited transcript of the program follows.