Ernst Bamberg, Ed Boyden, Karl Deisseroth, Peter Hegemann, Gero Miesenböck, and Georg Nagel will receive a storied science prize in recognition of their extraordinary contributions related to the invention and refinement of optogenetics. The Rumford Prize has been awarded previously to Thomas Edison in 1895 for his work in electric lighting; Edwin Land in 1945 for his applications in polarized light and photography; Enrico Fermi in 1953 for his studies of radiation theory and nuclear energy; and Federico Capasso and Alfred Cho in 2015 for their contributions to the field of laser technology.