On March 9, 2025, the Academy’s Los Angeles Committee hosted an event for members and guests on Science and Creativity. The program began with welcome remarks from Academy President Laurie L. Patton, followed by the presentation of the Rumford Prize to Andrea M. Ghez and then a brief introduction from Cynthia M. Friend (The Kavli Foundation; Harvard University). The program continued with a discussion on how creativity and imagination fuel scientific discovery, and how science inspires artistic expression. The discussion, moderated by Thomas F. Rosenbaum (California Institute of Technology), featured Andrea M. Ghez (University of California, Los Angeles), Kip S. Thorne (California Institute of Technology), and Risa H. Wechsler (Stanford University). An edited transcript of the program follows. The event was supported in part by The Kavli Foundation.